Search on: UNNA-THOST SYNDROME 
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Descriptor English:   Keratoderma, Palmoplantar, Diffuse 
Descriptor Spanish:   Queratodermia Palmar y Plantar Difusa 
Descriptor Portuguese:   Ceratodermia Palmar e Plantar Difusa 
Synonyms English:   Thost-Unna Syndrome
Tylosis
Unna-Thost Syndrome  
Tree Number:   C16.320.850.475.440
C17.800.428.435.440
C17.800.827.475.440
Definition English:   An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present. 
Indexing Annotation English:   do not confuse with KERATODERMA, PALMOPLANTAR
History Note English:   90 
Allowable Qualifiers English:  
blood cerebrospinal fluid
chemically induced classification
congenital complications
diet therapy diagnosis
drug therapy economics
ethnology embryology
enzymology epidemiology
etiology genetics
history immunology
metabolism microbiology
mortality nursing
pathology prevention & control
physiopathology parasitology
psychology radiography
rehabilitation radionuclide imaging
radiotherapy surgery
therapy urine
ultrasonography veterinary
virology  
Record Number:   24759 
Unique Identifier:   D015776 

Occurrence in VHL:
 

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